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Search Results for " interferon a 1 "

Targets Recommended: Others IFNAR

45

抑制剂 & 化合物

1

天然产物

1934

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T11630	IFN alpha-IFNAR-IN-1 hydrochloride	Others; IFNAR	Immunology/Inflammation; Others
	IFN alpha-IFNAR-IN-1 hydrochloride 是 IFN-α 和 IFNAR 相互作用的抑制剂。 IFN alpha-IFNAR-IN-1 hydrochloride 抑制 BM-pDCs 的 MVA 诱导的 IFN-α 反应，IC50 为 2-8 μM。
T13736	Interferon receptor inducer-1	IFNAR	Immunology/Inflammation
	Interferon receptor inducer-1 是一种干扰素(IFN)受体诱导剂，可用于干扰素诱导参与的紊乱性疾病的研究。
T11035	diABZI STING agonist-1 (Tautomerism) diABZI STING agonist (Compound 3)	STING	Immunology/Inflammation
	diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) 是一个选择性的干扰素基因刺激受体 (STING) 的激动剂，其在人和小鼠中的 EC50 值分别为 130 nM 和 186 nM。。
T6964	Resiquimod R848,雷西莫特,S28463	HCV Protease; TLR	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Resiquimod (R848) 是一种 Toll 样受体7/8的激动剂，可诱导细胞因子上调。
T70965	GSK-2245035 maleate
	GSK-2245035 maleate is a selective Toll-like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties.
T61455	BSP16
	BSP16 is a highly potent and orally active STING agonist, capable of selectively stimulating the interferon genes pathway. This compound, BSP16, holds great potential for cancer research [1].
T38159	STING Agonist 12b
	STING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 μM, respectively). STING agonist 12b (40 μM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells. 1.Hou, S., Lan, X.-j., Li, W., et al.Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonistsBioorg. Chem.95103556(2020)
T80570	Dazukibart	IFNAR	Immunology/Inflammation
	Dazukibart为针对小鼠源性干扰素β1(IFNB1)设计的人源化IgG1κ单克隆抗体。
T11482	GSK2245035	Others	Others
	GSK2245035 is a highly selective intranasal TLR7 agonist with preferential Type-1 interferon (IFN)-stimulating properties (pEC50s: 9.3 and 6.5 for IFNα and TFNα). It effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood
T81082	STING-IN-7	STING	Immunology/Inflammation
	STING-IN-7（化合物 21），作为一种STING抑制剂，具有11.5 nM的IC50值，能够抑制STING与干扰素调节因子 3 (IRF3) 的磷酸化。
T70291	PCC0208018
	PCC0208018 is a novel activator of effector T cells, enhancing T cell proliferation and activation to release interferon gamma (IFN-γ) and interleukin-2 (IL-2) without blocking the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) binding and not directly affecting tumor cell viability in vitro.
T26895	BRD0476 BRD-0476,ML 187,ML187,ML-187,BRD 0476
	BRD0476 is a suppressor of pancreatic β-cell apoptosis. BRD0476 inhibits interferon-gamma (IFN-γ)-induced Janus kinase 2 (JAK2) and signal transducer and activation of transcription 1 (STAT1) signaling to promote β-cell survival. BRD0476 inhibits JAK-STAT
T83147	Albinterferon alfa-2B alb-IFN
	Albinterferon alfa-2B (alb-IFN) 是融合了人白蛋白基因的重组干扰素 alfa-2b。它适用于慢性丙型肝炎的研究。
T38162	STING18
	STING18 is a competitive ligand of stimulator of interferon genes (STING; IC50 = 0.068 μM in a radioligand binding assay).1 It inhibits cGAMP-induced IFN-β production (IC50 = 11 μM) but does not stimulate IFN-β production (EC50 = >30 μM) in THP-1 cells. \|1. Siu, T., Altman, M.D., Baltus, G.A., et al. Discovery of a novel cGAMP competitive ligand of the inactive form of STING. Med. Chem. Lett. 10(1), 92-97 (2019).
T26828	BIT225 BIT 225,BIT-225
	BIT-225 is a NCp7 zinc finger inhibitor. BIT225 inhibits HIV-1 replication in myeloid dendritic cells. BIT225 inhibits HIV-1 release from human macrophages. BIT225 inhibits bovine viral diarrhea virus in vitro and shows synergism with recombinant interfer
T76853	Ropeginterferon alfa-2b
	Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft) 为单聚乙二醇化IFN-α类化合物，主要应用于骨髓增性肿瘤研究领域。
T74268	STING agonist-13
	STINGagonist-13 是一种STING 激动剂，通过STING 介导的免疫激活进行癌症免疫。STINGagonist-13 可刺激STING 下游信号传导并促进 I 型干扰素免疫反应。STINGagonist-13 能显著降低肿瘤体积并具有免疫记忆衍生的癌症抑制活性。
T77038	Interferon alfa
	Interferon alfa 是 I 型干扰素，可激活新基因，对靶细胞产生有效抗病毒和抗增殖活性。Interferon alfa 的信号传导需要 Stat1和 Stat2 的受体依赖性激活，形成异源二聚化 STAT。STAT 复合物与 DNA 结合蛋白 IRF-9 (p48) 结合并形成 ISGF-3 (IFN 刺激基因因子 3)。随后由 ISGF-3 进一步激活驱动基因，实现抗病毒功能。
T81331	QL-1200186	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	QL-1200186为具备口服活性与选择性的TYK2抑制剂。经口服后，该药剂量依赖性抑制因interleukin-12刺激所诱导的interferon-γ产生，并在银屑病模型小鼠中显著改善皮肤病变状况。
T82043	Iso5-2DC18
	Iso5-2DC18是用于合成含胺脂质的化合物。该脂质适用于mRNA传递、激活STING通路及表达抗肿瘤免疫效应。
T61574	PD-L1-IN-1
	PD-L1-IN-1, a powerful PD-L1 inhibitor, demonstrated an IC50 of 115 nM. By forming a robust bond with the PD-L1 protein, PD-L1-IN-1 effectively suppressed tumor growth by enhancing the antitumor immune activity of peripheral blood mononuclear cells in co-cultures with PD-L1 expressing cancer cells (PC9 and HCC827 cells). It significantly elevated the release of interferon γ and induced apoptosis in cancer cells, while exhibiting minimal cytotoxicity in healthy cells [1].
T73746	diABZI STING agonist-1
	diABZISTINGagonist-1是一种针对干扰素基因刺激受体（STING）的选择性激动剂，其在人类和小鼠中的EC50值分别是130 nM和186 nM。
T77087	Mipeginterferon alfa-2b
	Mipeginterferon alfa-2b 是一种干扰素IFNA2b 类似物。包括一个 N 末端和 10 个赖氨酸 N6 在内的 11 个氨基，平均被取代掉 5 个。Mipeginterferon alfa-2b 的相对分子质量为 40 kDa。
T74726	CL845
	CL845 是 STING 激动剂 CL656 的类似物。CL845 可用于合成靶向 STING（干扰素基因刺激物）的可结合 PRR 配体。CL845 可用于癌症、免疫系统疾病或感染的研究。
T75086	Dazostinag
	Dazostinag (TAK-676 free base) 为干扰素基因刺激剂 (STING) 蛋白的激动剂，展现出抗肿瘤活性。它能作为有效载荷 (payload) 用于合成抗体偶联活性分子 (ADC) 的构建。
T79320	Antitumor agent-114	STING	Immunology/Inflammation
	Antitumor agent-114为一种强效STING激动剂，具有激活免疫功能并在乳腺癌小鼠模型中缩减肿瘤体积的作用，适用于免疫与癌症疾病研究之用。
T38160	STING Agonist 1a
	STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 μM). STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 . 1.Hou, H., Yang, R., Liu, X., et al.Discovery of triazoloquinoxaline as novel STING agonists via structure-based vir...
T77003	Ezabenlimab
	Ezabenlimab (BI-754091) 是一种抗PD-1单克隆抗体，结合PD-1的 Kd 为 6 nM (CHO 细胞)。Ezabenlimab 能够阻断PD-1与PD-L1和PD-L2的相互作用。Ezabenlimab 还增加 T 细胞内的 γ 干扰素分泌，抑制体内肿瘤生长。
T73696	Peginterferon alfa-2b
	Peginterferon alfa-2b 是一种免疫调节剂。Peginterferon alfa-2b 是一种共价连接 PEG 的重组 alfa-2b 干扰素。Peginterferon alfa-2b 减少HIV 中的病毒 DNA。Peginterferon alfa-2b 可用于黑色素瘤的研究。
T75011	STING-IN-5	STING	Immunology/Inflammation
	STING-IN-5为有效STING抑制剂，IC50达1.15 μM，能在巨噬细胞内抑制LSP诱导之NO合成，从而抑制炎症反应，主用于抗炎疾病与败血症研究。
T76943	Cepeginterferon alfa-2b
	Cepeginterferon alfa-2b是一种聚乙二醇化干扰素, 其聚乙二醇基由分子量为20 kDa的PEG构成。该化合物广泛应用于丙型肝炎病毒(HCV)、真性红细胞增多症(PV)和原发性血小板增多症(ET)等疾病的研究中。
T38158	StA-IFN-1
	StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 μM in a GFP reporter assay for IFN induction similar to TPCA-1 , which specifically inhibits the IKKβ component of the IFN induction pathway. It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib , which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-β, but not ISG MxA, mRNA, suggesting that it is selective f...
T35422	5'-pApA (sodium salt)
	5'-pApA is a linearized form of cyclic di-AMP, a bacterial second messenger that activates the host innate immune system through stimulator of interferon genes (STING).1,2,3,4It is a metabolite of cyclic di-AMP formedviahydrolysis by various phosphodiesterases (PDEs).55'-pApA is intended for use as a negative control for cyclic di-AMP signaling. 1.Burdette, D.L., Monroe, K.M., Sotelo-Troha, K., et al.STING is a direct innate immune sensor of cyclic-di-GMPNature478(7370)515-518(2011) 2.Parvatiyar...
T79313	BI 7446	STING	Immunology/Inflammation
	BI 7446 是一种基于环状二核苷酸 (CDN) 的高效、特异性STING (干扰素基因刺激蛋白) 激动剂。它能激活所有五种STING变体并在体外诱导肿瘤特异性的免疫介导反应，从而消除肿瘤。此化合物适用于免疫肿瘤学领域的研究。
T83901	BDW568
	BDW568是一种刺激素干扰素基因（STING）的激动剂，同时是BDW-OH的前药形式。在使用THP-1细胞的报告基因测定中，它能诱导STING转录活性（EC50 = 7.6 µM）。BDW568（50 µM）在THP-1细胞中诱导TANK结合激酶1（TBK1）和IFN调节因子3（IRF3）的磷酸化。
T61968	PD-1/PD-L1-IN 6
	PD-1/PD-L1-IN 6 (compound A13) 是有效的PD-1/PD-L1相互作用抑制剂（IC50为 132.8 nM）。PD-1/PD-L1-IN 6 显示出显著的免疫调节活性。在 Hep3B/OS-8/hPD-L1 与 CD3 T 细胞共培养模型中，PD-1/PD-L1-IN 6显著提高干扰素 -γ 分泌，且无明显毒性作用。在 T 细胞-肿瘤共培养模型中，PD-1/PD-L1-IN 6恢复免疫应答。
T36461	CAY10748 CAY10748
	CAY10748 is an agonist of stimulator of interferon genes (STING; IC50= 0.3794 μM in a competition binding assay).1It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 μM, respectively, in a reporter assay). It induces phosphorylation of STING at the serine in position 366, as well as phosphorylation of TBK1 and IFN regulatory factor 3 (IRF3), indicating activation of the STING-TBK1-IRF3 signaling pathway. CAY10748 increases the secretion of IFN-β an...
T38320	93-O17S 93-O17S
	93-O17S is a chalcogen-containing cationic lipidoid.1It has been used in the synthesis of lipid nanoparticles (LPNs) for the delivery of Cre recombinase and ribonucleoproteins for genome editing in mice. LPNs containing 93-O17S have been used for the intratumoral delivery of cGAMP to enhance cross-presentation of tumor antigens and stimulation of interferon genes (STING) activation in a B16/F10 murine melanoma model.2 1.Li, Y., Yang, T., Yu, Y., et al.Combinatorial library of chalcogen-containin...
T74693	CDN-A
	CDN-A为一种环二核苷酸，主要用于抗体-活性分子偶联物(ADC)的合成。作为先天免疫及适应性免疫反应的关键激活剂，环状二核苷酸能由内源性外来DNA或侵入性细菌病原体生成，在人体内通过促进干扰素基因表达激活先天免疫系统。
T75090	STING agonist-22
	STINGagonist-22 (CF501) 是一种有效的非核苷酸STING 激动剂。STINGagonist-22 是一种佐剂，通过激活STING 来诱导 I 型干扰素 (IFN-I) 反应和促炎细胞因子的产生。STINGagonist-22 可用作增强原始蛋白疫苗的佐剂，产生有效、广泛和长期的免疫保护。STINGagonist-22 可用于 SARS-CoV-2 变异和 sarbecovirus 疾病研究。
T38161	STING Agonist C11 STING Agonist C11
	STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses gro...
T23028	MRT67307 HCl (1190378-57-4 free base) MRT67307 HCl	Others	Others
	MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it is a salt inducible kinase (SIK) inhibitor with IC50 value of 250, 67 and 430nM for SIK1, SIK2 and SIK3, respectively.<br />SIKs prevent the formation of regulatory macrophages and their inhibition induces increasing in some markers of regulatory macrophages, such as IL-10 and oth...
T83775	STING Agonist 12L Stimulator of Interferon Genes Agonist 12L
	STING激动剂12L是一种刺激干扰素基因(STING)的激动剂。它与野生型STING结合(IC50 = 1.15 µM)，以及STING的R232、AQ和Q变体(IC50分别为1.06、0.61和1.12 µM)，并在THP-1和RAW 264.7细胞中诱导报告基因表达(EC50分别为0.38和12.94 µM)。STING激动剂12L (5 µM)在THP-1细胞中诱导IFNB1、CXCL10和IL6 mRNA的表达。在体内，STING激动剂12L (10 mg/kg)提高了血浆IFN-β水平，并且在B16/F10小鼠黑色素瘤模型中减少了肿瘤体积和肺转移灶的数量。
T83841	STING Agonist D61 D61,Stimulator of Interferon Genes Agonist D61
	STING激动剂D61（D61）是干扰素基因刺激剂(STING)的激动剂。它在基于细胞的分析中诱导IFN3诱导的分泌性碱性磷酸酶(SEAP)报告基因和IFN-β诱导的报告基因的表达（EC50分别为52.9和116 nM）。D61（4, 6, 和8 µM）增加了编码IFN-β和化学因子（C-X-C基序）配体10（CXCL10）的mRNA的表达以及TANK结合激酶1（TBK1）、IRF3和STING在THP-1单核细胞中的磷酸化。在体内，D61（每隔一天0.25 mg/kg）在CT26小鼠结肠癌模型中减少肿瘤体积，而不影响体重。
T83874	S-72
	S-72是一种微管聚合抑制剂，以1, 3, 10 µM的浓度在无细胞测定中抑制微管聚合，并在MCF-7和耐紫杉醇的MCF-7/T乳腺癌细胞中降低细胞活性（IC50分别为15.64和26.32 nM）。50 nM浓度的S-72能抑制MCF-7和MCF-7/T细胞的迁移和侵袭，并减少划痕实验中的伤口闭合百分比。100 nM的S-72在MCF-7/T细胞中诱导G2/M期的细胞周期阻滞以及凋亡，并在同一浓度下抑制这些细胞中干扰素基因激活剂（STING）的激活。以每天15 mg/kg的剂量，S-72抑制了耐紫杉醇的MCF-7/T和MX-1/T小鼠异种移植模型中的肿瘤生长。

化合物

IFN alpha-IFNAR-IN-1 hydrochloride

Cat.No: T11630

Target: Others, IFNAR

Interferon receptor inducer-1

Cat.No: T13736

Target: IFNAR

diABZI STING agonist-1 (Tautomerism)

Cat.No: T11035

Synonym: diABZI STING agonist (Compound 3)

Target: STING

Cat.No: T6964

Synonym: R848,雷西莫特,S28463

Target: HCV Protease, TLR

GSK-2245035 maleate

Cat.No: T70965

Cat.No: T61455

STING Agonist 12b

Cat.No: T38159

Cat.No: T80570

Target: IFNAR

Cat.No: T11482

Target: Others

Cat.No: T81082

Target: STING

Cat.No: T70291

Cat.No: T26895

Synonym: BRD-0476,ML 187,ML187,ML-187,BRD 0476

Albinterferon alfa-2B

Cat.No: T83147

Synonym: alb-IFN

Cat.No: T38162

Cat.No: T26828

Synonym: BIT 225,BIT-225

Ropeginterferon alfa-2b

Cat.No: T76853

STING agonist-13

Cat.No: T74268

Interferon alfa

Cat.No: T77038

Cat.No: T81331

Target: JAK

Cat.No: T82043

Cat.No: T61574

diABZI STING agonist-1

Cat.No: T73746

Mipeginterferon alfa-2b

Cat.No: T77087

Cat.No: T74726

Cat.No: T75086

Antitumor agent-114

Cat.No: T79320

Target: STING

STING Agonist 1a

Cat.No: T38160

Cat.No: T77003

Peginterferon alfa-2b

Cat.No: T73696

Cat.No: T75011

Target: STING

Cepeginterferon alfa-2b

Cat.No: T76943

Cat.No: T38158

5'-pApA (sodium salt)

Cat.No: T35422

Cat.No: T79313

Target: STING

Cat.No: T83901

PD-1/PD-L1-IN 6

Cat.No: T61968

Cat.No: T36461

Synonym: CAY10748

Cat.No: T38320

Synonym: 93-O17S

Cat.No: T74693

STING agonist-22

Cat.No: T75090

STING Agonist C11

Cat.No: T38161

Synonym: STING Agonist C11

MRT67307 HCl (1190378-57-4 free base)

Cat.No: T23028

Synonym: MRT67307 HCl

Target: Others

STING Agonist 12L

Cat.No: T83775

Synonym: Stimulator of Interferon Genes Agonist 12L

STING Agonist D61

Cat.No: T83841

Synonym: D61,Stimulator of Interferon Genes Agonist D61

Cat.No: T83874

Cat. No.	Product Name	Target	Signaling Pathways
T73717	cGAMP diammonium
	cGAMP (Cyclic GMP-AMPP) diammonium 是一种内源性第二信使，通过触发干扰素的产生来响应胞浆 DNA。它通过激活干扰素基因刺激因子（STING），启动信号级联，进而导致I型干扰素及其他免疫介质的生成。

天然产物

cGAMP diammonium

Cat.No: T73717

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04578	Interferon alpha 1/IFNA1 Protein, Human, Recombinant (His) Interferon α1,IFN-alphaD...	Human	Yeast
	IFNA1, also known as IFN-alpha and IFNA, belongs to the alpha/beta interferon family. Interferons(IFNs) are proteins made and released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites, or tumor cells. They belong to the large class of glycoproteins known as cytokines. IFNs stimulate the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow for communication between cells to trigger the protective defenses of the immune...
TMPY-02647	IFNAR1 Protein, Human, Recombinant (His) interferon (alpha, beta ...	Human	HEK293
	Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR...
TMPY-02743	Interferon alpha 1/IFNA1 Protein, Rat, Recombinant (hFc) Interferon α1,干扰素,interferon, α	Rat	HEK293
	IFNA1, also known as IFN-alpha and IFNA, belongs to the alpha/beta interferon family. Interferons(IFNs) are proteins made and released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites, or tumor cells. They belong to the large class of glycoproteins known as cytokines. IFNs stimulate the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow for communication between cells to trigger the protective defenses of the immune...
TMPY-02865	Interferon alpha 1/IFNA1 Protein, Rat, Recombinant (His) interferon, alpha 1,...	Rat	HEK293
	IFNA1, also known as IFN-alpha and IFNA, belongs to the alpha/beta interferon family. Interferons(IFNs) are proteins made and released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites, or tumor cells. They belong to the large class of glycoproteins known as cytokines. IFNs stimulate the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow for communication between cells to trigger the protective defenses of the immune...
TMPY-04634	Interferon alpha 1/IFNA1 Protein, Mouse, Recombinant (His) Ifa1,Interferon α1,i...	Mouse	Yeast
	IFNA1, also known as IFN-alpha and IFNA, belongs to the alpha/beta interferon family. Interferons(IFNs) are proteins made and released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites, or tumor cells. They belong to the large class of glycoproteins known as cytokines. IFNs stimulate the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow for communication between cells to trigger the protective defenses of the immune...
TMPK-00075	IFN-alpha 1/IFNA1 Protein, Human, Recombinant (hFc) IFN-α-1/13,IFN α1,IFN al...	Human	HEK293
	IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes.
TMPK-00074	IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc) IFN-α-1/13,IFN alpha...	Mouse	HEK293
	IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes.
TMPY-03927	IFNAR1 Protein, Rhesus, Recombinant interferon (α, β and ω) receptor 1	Rhesus	HEK293
	Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR...
TMPY-03829	IFNAR1 Protein, Rhesus, Recombinant (hFc) interferon (α, β and Ω) receptor 1	Rhesus	HEK293
	Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR...
TMPY-04254	IFNAR1 Protein, Rhesus, Recombinant (His) interferon (alpha, beta ...	Rhesus	HEK293
	Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR...
TMPY-02634	IFNAR1 Protein, Human, Recombinant (hFc) interferon (α, β and Ω) receptor 1	Human	HEK293
	Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR...
TMPY-01489	IFNAR1 Protein, Mouse, Recombinant (His) Ifrc,Ifar,CD118,interferon	Mouse	HEK293
	Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR...
TMPJ-00331	IFNAR1 Protein, Rhesus macaque, Recombinant (His) IFN-al,CRF2-1,IFN-alpha/...	Rhesus macaque	Human Cells
	Interferon‑alpha/beta receptor 1 (IFN‑ alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphory...
TMPH-00279	Interferon tau-1/IFNT1 Protein, Bovine, Recombinant (His)	Bovine	Yeast
	Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian...
TMPH-00278	Interferon tau-1/IFNT1 Protein, Bovine, Recombinant (E. coli, His)	Bovine	E. coli
	Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian...
TMPY-02355	IFNGR1 Protein, Mouse, Recombinant (His) interferon gamma receptor 1	Mouse	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins ...
TMPY-01151	IFNGR1 Protein, Human, Recombinant (His) IMD27B,IFNGR,interferon gamma rec...	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins ...
TMPY-04799	IFNAR2 Protein, Human, Recombinant (His), Biotinylated IFN-R,interferon (α, β and Ω) receptor 2,I...	Human	HEK293
	Interferon-alpha/beta receptor beta chain (IFNAR2) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Initial cell-surface IFNAR2 expression at diagnosis assessed by flow cytometry was widely distributed but showed overall significantly higher expression in CML patients when compared with normal c...
TMPY-03273	IL-18 Protein, Mouse, Recombinant interleukin 18,白细胞介素,白介素,Il-18,Igif	Mouse	E. coli
	Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its bi...
TMPY-03050	CXCL5 Protein, Human, Recombinant ENA-78,SCYB5,chemokine (C-X-C motif) ligan...	Human	E. coli
	CXCL5 is a small cytokine belonging to the CXC chemokine family. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. CXCL5 is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. It also can be detected in eosinophils, and can be inhibited with the type II interferon. CXCL5 plays a role in reducing sensitivity to sunburn pain in some subjects, and is a potential target which can be utili...
TMPY-00277	IL-18 Protein, Human, Recombinant IGIF,IL-18,IL1F4,IL-1g,Interleuki...	Human	E. coli
	Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its bi...
TMPY-00136	IL-29 Protein, Human, Recombinant interferon, λ1,IL-29,IL29,interferon	Human	HEK293
	Interleukin-29 (IL-29), also known as cytokine Zcyto21, Interferon lambda-1, IFN-lambda-1, and IFNL1, is a secreted protein that belongs to the IL-28 / IL-29 family. IL-29 is a cytokine with immunomodulatory activity. IL-29 is highly similar in amino acid sequence to the IL-28. IL-28 and IL-29 are induced by a viral infection and showed antiviral activity. IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan c...
TMPY-01928	IL-18 Protein, Rhesus, Recombinant (His) 白细胞介素,interleukin 18,白介素	Rhesus	E. coli
	Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its bi...
TMPY-00500	Latent TGF beta 1 Protein, Mouse, Recombinant (His) transforming growth factor, beta ...	Mouse	HEK293
	TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decreas...
TMPY-04211	Latent TGF beta 1 Protein, Cynomolgus, Recombinant (His) transforming growth factor, β1,TG...	Cynomolgus	HEK293
	TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decreas...
TMPY-00608	TGF beta 1 Protein, Rat/Mouse, Recombinant transforming growth factor, beta ...	Mouse,Rat	HEK293
	TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decreas...
TMPY-03945	Latent TGF beta 1 Protein, Rat, Recombinant (His) TGF β1,transforming growth factor...	Rat	HEK293
	TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decreas...
TMPY-01133	Latent TGF beta 1 Protein, Human, Recombinant (His) CED,DPD1,transforming growth fact...	Human	HEK293
	TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decreas...
TMPY-02638	TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant transforming growth factor, beta ...	Human,Rhesus,Cynomolgus,Canine	CHO
	TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decreas...
TMPY-03346	IFNGR1 Protein, Rat, Recombinant (hFc) interferon gamma receptor 1	Rat	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins ...
TMPY-05831	IFNGR1 Protein, Human, Recombinant (hFc) IFNGR,interferon gamma receptor <...	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins ...
TMPY-03379	IFNGR1 Protein, Cynomolgus, Recombinant (hFc) interferon gamma receptor 1	Cynomolgus	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins ...
TMPY-03668	IFNGR1 Protein, Cynomolgus, Recombinant (His) interferon γ receptor 1,interferon	Cynomolgus	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins ...
TMPY-02354	IFNGR1 Protein, Mouse, Recombinant (hFc) IFN-gammaR,Ifgr,interferon γ rece...	Mouse	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins ...
TMPY-02549	GBP1 Protein, Human, Recombinant (His) guanylate binding protein 1,GBP	Human	HEK293
	Guanylate-binding protein 1 (GBP-1) is a member of the GBP family whose members are GTPases induced in response to interferon-λ (IFN-λ), with seven highly homologous members in humans, termed HuGBP-1 to HuGBP-7. GBP-1 expression is induced by type1 and type2 interferons, including IFN-λ and also by interleukin-1β (IL-1β), IL-1α, and tumor necrosis factor-α (TNF-α). GBP-1 is key to the protective immunity against microbial and viral pathogens. GBP-1 was only secreted from endothelial cells. Secre...
TMPJ-01328	ZBP1 Protein, Human, Recombinant (His) Tumor Stroma and Activat...	Human	E. coli
	Z-DNA Binding Protein 1 (ZBP1) is a protein with 2 DRADA repeats. ZBP1 is highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow, and spleen. ZBP1 participates in the detection of viral and bacterial DNA from by the host's innate immune system. It plays a role in host defense against tumors and pathogens. ZBP1 Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream ...
TMPJ-00070	IL-18 Protein, Human, Recombinant (His) GIF,IL-1 γ,白细胞介素,Iboctadekin,Interleukin-<...	Human	Human Cells
	Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. After...
TMPJ-01206	Sting Protein, Human, Recombinant (Sumo & His) TMEM173,Mediator of IRF3 activ	Human	E. coli
	Stimulator of Interferon Gene(Sting,TMEM173) belongs to the TMEM173 family. STING is 379 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-20), four transmembrane segments (aa 21-173), and a C-terminal cytoplasmic domain (aa 174-379). It ubiquitously expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophagesand. Its subunit structure associated with the MHC-II complex and Interacts with DDX58/RIG-I, MAVS and SSR2,...
TMPY-04478	IP6K1/IHPK1 Protein, Human, Recombinant (His & GST) inositol hexakisphosphate kinase ...	Human	Baculovirus-Insect Cells
	IP6K1 (Inositol Hexakisphosphate Kinase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. IHPK1 is an inositol hexaphosphate kinase (IHPK) protein that belongs to the inositol phosphokinase (IPK) family. IHPK proteins are likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). IHPK1 may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth-suppressive and...
TMPY-01640	IFNAR2 Protein, Human, Recombinant (hFc) interferon (α, β and ω) receptor 2,IFN...	Human	HEK293
	Interferon-alpha/beta receptor beta chain (IFNAR2) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Initial cell-surface IFNAR2 expression at diagnosis assessed by flow cytometry was widely distributed but showed overall significantly higher expression in CML patients when compared with normal c...
TMPY-01642	IFNAR2 Protein, Human, Recombinant (His) IFNARB,IFNABR,interferon (α, β	Human	HEK293
	Interferon-alpha/beta receptor beta chain (IFNAR2) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Initial cell-surface IFNAR2 expression at diagnosis assessed by flow cytometry was widely distributed but showed overall significantly higher expression in CML patients when compared with normal c...
TMPJ-01084	CXCL9 Protein, Human, Recombinant (His) Monokine Induced by Interferon-γ,Gamma...	Human	Human Cells
	Chemokine (C-X-C Motif) Ligand 9 (CXCL9) belongs to the intercrine alpha (chemokine CXC) family. It is secreted by interferon stimulated monocytes, macrophages and endothelial cells, which elicits chemotactic functions by interacting with the chemokine receptor CXCR3. CXCL9 acts as a Th1 (type 1 helper T) cell chemoattractant and plays a role in the growth, activation and movement of cells associated with immune and inflammatory responses, and in tumour growth inhibition. It is closely related t...
TMPY-04790	CXCL5 Protein, Mouse, Recombinant (His) AMCF-II,GCP-2,Scyb6,LIX,chemokine (C-X-C motif) lig...	Mouse	Yeast
	CXCL5 is a small cytokine belonging to the CXC chemokine family. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. CXCL5 is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. It also can be detected in eosinophils, and can be inhibited with the type II interferon. CXCL5 plays a role in reducing sensitivity to sunburn pain in some subjects, and is a potential target which can be utili...
TMPJ-01095	CD161 Protein, Human, Recombinant (N-hFc) Killer cell lectin-like receptor subfamily B member...	Human	Human Cells
	Killer cell lectin-like receptor subfamily B, member 1(KLRB1) is a single-pass type II membrane protein which contains 1 C-type lectin domain. KLRB1 plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. It acts as...
TMPJ-01094	CD161 Protein, Human, Recombinant (C-hFc) Killer cell lectin-like receptor subfamily B member...	Human	Human Cells
	Killer cell lectin-like receptor subfamily B, member 1(KLRB1) is a single-pass type II membrane protein which contains 1 C-type lectin domain. KLRB1 plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. It acts as...
TMPY-00139	IFNAR2 Protein, Cynomolgus, Recombinant (His) interferon (α, β and Ω) receptor 2,int...	Cynomolgus	HEK293
	Interferon-alpha/beta receptor beta chain (IFNAR2) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Initial cell-surface IFNAR2 expression at diagnosis assessed by flow cytometry was widely distributed but showed overall significantly higher expression in CML patients when compared with normal c...
TMPY-01947	IL-29 Protein, Human, Recombinant (His) IL-29,IFNL1,白介素,白细胞介素,interferon, la	Human	HEK293
	Interleukin-29 (IL-29), also known as cytokine Zcyto21, Interferon lambda-1, IFN-lambda-1, and IFNL1, is a secreted protein that belongs to the IL-28 / IL-29 family. IL-29 is a cytokine with immunomodulatory activity. IL-29 is highly similar in amino acid sequence to the IL-28. IL-28 and IL-29 are induced by a viral infection and showed antiviral activity. IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan c...
TMPY-01775	AIM2 Protein, Human, Recombinant (GST) absent in melanoma 2,PYHIN4	Human	Baculovirus-Insect Cells
	AIM2, Absent In Melanoma 2 is a member of the interferon-inducible HIN-200 protein family that contains an amino-terminal pyrin domain and a carboxy-terminal oligonucleotide/oligosaccharide-binding domain, senses cytoplasmic DNA by means of its oligonucleotide/oligosaccharide-binding domain and interacts with ASC (apoptosis-associated speck-like protein containing a CARD) through its pyrin domain to activate caspase-1. In response to foreign cytoplasmic DNA, AIM2 forms an inflammasome, resulting...
TMPJ-01425	SARS-CoV-2 NSP1 Protein (His) SARS-CoV 2 nsp1,SARS-CoV 2 Le...	SARS-CoV-2	E. coli
	The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ∼30 kb linear, non-segmented, capped, polycistronic, polyadenylated RNA molecule, the first two-third of which is directly translated into two large polyproteins. These two polypeptides are processed into 16 non-structural proteins (nsps), forming the replicase complex, which is active in the cytoplasm in close associa...
TMPY-03897	Fractalkine Protein, Canine, Recombinant (hFc) chemokine (C-X3-C motif) ligand 1	Canine	HEK293
	Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, m...
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重组蛋白

Interferon alpha 1/IFNA1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04578

Species: Human

Expression System: Yeast

IFNAR1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02647

Species: Human

Expression System: HEK293

Interferon alpha 1/IFNA1 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-02743

Species: Rat

Expression System: HEK293

Interferon alpha 1/IFNA1 Protein, Rat, Recombinant (His)

Cat.No: TMPY-02865

Species: Rat

Expression System: HEK293

Interferon alpha 1/IFNA1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04634

Species: Mouse

Expression System: Yeast

IFN-alpha 1/IFNA1 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00075

Species: Human

Expression System: HEK293

IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00074

Species: Mouse

Expression System: HEK293

IFNAR1 Protein, Rhesus, Recombinant

Cat.No: TMPY-03927

Species: Rhesus

Expression System: HEK293

IFNAR1 Protein, Rhesus, Recombinant (hFc)

Cat.No: TMPY-03829

Species: Rhesus

Expression System: HEK293

IFNAR1 Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-04254

Species: Rhesus

Expression System: HEK293

IFNAR1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02634

Species: Human

Expression System: HEK293

IFNAR1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01489

Species: Mouse

Expression System: HEK293

IFNAR1 Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPJ-00331

Species: Rhesus macaque

Expression System: Human Cells

Interferon tau-1/IFNT1 Protein, Bovine, Recombinant (His)

Cat.No: TMPH-00279

Species: Bovine

Expression System: Yeast

Interferon tau-1/IFNT1 Protein, Bovine, Recombinant (E. coli, His)

Cat.No: TMPH-00278

Species: Bovine

Expression System: E. coli

IFNGR1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02355

Species: Mouse

Expression System: HEK293

IFNGR1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01151

Species: Human

Expression System: HEK293

IFNAR2 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-04799

Species: Human

Expression System: HEK293

IL-18 Protein, Mouse, Recombinant

Cat.No: TMPY-03273

Species: Mouse

Expression System: E. coli

CXCL5 Protein, Human, Recombinant

Cat.No: TMPY-03050

Species: Human

Expression System: E. coli

IL-18 Protein, Human, Recombinant

Cat.No: TMPY-00277

Species: Human

Expression System: E. coli

IL-29 Protein, Human, Recombinant

Cat.No: TMPY-00136

Species: Human

Expression System: HEK293

IL-18 Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-01928

Species: Rhesus

Expression System: E. coli

Latent TGF beta 1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00500

Species: Mouse

Expression System: HEK293

Latent TGF beta 1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-04211

Species: Cynomolgus

Expression System: HEK293

TGF beta 1 Protein, Rat/Mouse, Recombinant

Cat.No: TMPY-00608

Species: Mouse,Rat

Expression System: HEK293

Latent TGF beta 1 Protein, Rat, Recombinant (His)

Cat.No: TMPY-03945

Species: Rat

Expression System: HEK293

Latent TGF beta 1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01133

Species: Human

Expression System: HEK293

TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant

Cat.No: TMPY-02638

Species: Human,Rhesus,Cynomolgus,Canine

Expression System: CHO

IFNGR1 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-03346

Species: Rat

Expression System: HEK293

IFNGR1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05831

Species: Human

Expression System: HEK293

IFNGR1 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPY-03379

Species: Cynomolgus

Expression System: HEK293

IFNGR1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-03668

Species: Cynomolgus

Expression System: HEK293

IFNGR1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02354

Species: Mouse

Expression System: HEK293

GBP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02549

Species: Human

Expression System: HEK293

ZBP1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01328

Species: Human

Expression System: E. coli

IL-18 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00070

Species: Human

Expression System: Human Cells

Sting Protein, Human, Recombinant (Sumo & His)

Cat.No: TMPJ-01206

Species: Human

Expression System: E. coli

IP6K1/IHPK1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04478

Species: Human

Expression System: Baculovirus-Insect Cells

IFNAR2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-01640

Species: Human

Expression System: HEK293

IFNAR2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01642

Species: Human

Expression System: HEK293

CXCL9 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01084

Species: Human

Expression System: Human Cells

CXCL5 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04790

Species: Mouse

Expression System: Yeast

CD161 Protein, Human, Recombinant (N-hFc)

Cat.No: TMPJ-01095

Species: Human

Expression System: Human Cells

CD161 Protein, Human, Recombinant (C-hFc)

Cat.No: TMPJ-01094

Species: Human

Expression System: Human Cells

IFNAR2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-00139

Species: Cynomolgus

Expression System: HEK293

IL-29 Protein, Human, Recombinant (His)

Cat.No: TMPY-01947

Species: Human

Expression System: HEK293

AIM2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-01775

Species: Human

Expression System: Baculovirus-Insect Cells

SARS-CoV-2 NSP1 Protein (His)

Cat.No: TMPJ-01425

Species: SARS-CoV-2

Expression System: E. coli

Fractalkine Protein, Canine, Recombinant (hFc)

Cat.No: TMPY-03897

Species: Canine

Expression System: HEK293

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